张雪琼

发布时间:2019.01.16 15:09

   

  姓名:张雪琼

  性别:女

     出生年月:1982年2月

  学历/学位:博士研究生

  职称:副教授

  Email:zhangxq@whut.edu.cn

  教育经历 

  2007/09-2010/12,永利集团88304官网,材料科学与工程学院

  2003/09-2006/09,湖北中医药大学,药学院,硕士

  1999/09-2003/09,湖北中医药大学,药学院,学士

  研究经历

  2016/06-2017/06,美国北卡罗来纳大学教堂山分校,访问学者,合作导师 Leaf Huang。

  2014/09-至今,永利集团88304官网,永利集团88304官网制药工程系,副教授

  2011/05-2014/09,永利集团88304官网,永利集团88304官网制药工程系,讲师

  研究领域 

药物新剂型、天然药物化学 

  代表性科研项目 

  1.健脾生血颗粒(片)药效学及效应物质研究  80万元

  2.湖北省校企共建现代中药研发中心      25万元

  3.壳聚糖改性材料的研究           20万元

  代表性论文与专著

   1. Co-delivery of rose bengal and doxorubicin nanoparticles for combination photodynamic and chemo-therapy. Journal of biomedical nanotechnology, 2019, 15: 184-195.

  2. Nanotechnology: a promising method for oral cancer detection and diagnosis. Journal of nanobiotechnology, 2018, 16: 52-68.

  3. Nanoparticle-mediated trapping of Wnt family member 5A in tumor microenvironments enhances immunotherapy for B-Raf proto-oncogene-mutant melanoma, ACS Nano, 2018, 12(2): 1250-1261.

  4. Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma. Theranostics, 2018, 8(14): 3781-3796.

  5.Cisplatin-crosslinked glutathione-sensitive micelles loaded with doxorubicin for combination and targeted therapy of tumors. Carbohydrate Polymers 2017, 155: 407-415.

  6.A pH-Sensitive Nanosystem Based on carboxymethyl chitosan for tumor-targeted delivery of daunorubicin. Journal of biomedical nanotechnology, 2016, 12(8): 1688-1698.

  7.Glutathione-dependent micelles based on carboxymethyl chitosan for delivery of doxorubicin. Journal of biomaterials ccience-polymer edition, 2016, 27(18):1824-1840.

  8.Self-assembled nanoparticles based on folic acid modified carboxymethyl chitosan conjugated with targeting antibody, Journal of wuhan university of technology-materials science edition, 2016, 31(2): 446-453.

  9. pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate, Carbohydrate polymers, 2014, 111(20): 964-970.

  获得学术奖励 

  基于多学科组合技术的健脾生血颗粒深度开发, 湖北省科技厅, 湖北省科技进步奖, 二等奖, 2016

  

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