郑化

发布时间:2019.01.17 09:34

 

  姓名:郑化   

  性别:男   

  出生年月: 1965年9月 

  学位:博士

  职称:教授、博导 

  联系电话:     

  Emailzhenghua.whut@126.com 

    

  教育经历: 

  1982-1986年 北京师范大学化学系化学专业学习,获理学学士学位 

  1994-1996年 原武汉汽车工业大学高分子化工专业学习、获工学硕士学位 

  1998-2001年 武汉大学环境科学专业天然高分子研究方向学习、获工学博士学位  

工作经历:

11986-2000 原武汉汽车工业大学化学工程系助教、讲师、副教授

22001-至今 永利集团88304官网,二级教授、博士生导师、曾任永利集团88304官网化学工程学院院长、湖北省中药制剂工程技术研究中心主任、永利集团88304官网材料研究保护研究所所长,现任湖北省化学化工学会副理事长等

研究领域:

1、功能化合物设计、合成与应用

2、新材料设计、合成与应用

近年主持的主要科研项目:

1、国家自然科学基金项目

512731565050301950973088

2、国家工信部重大、重点、年度科技计划项目若干项

3、省部级重大、重点科技计划项目

2010CDA0402010BFA0212006AA301B172004E300152003AA303B0920127113043620091j0001

4、重大产业化项目

盐酸氨基葡萄糖产业化工艺的研究与开发、硫酸氨基葡萄糖产业化工艺的研究与开发、智能药物控释水凝胶的研究、多功能工艺助剂的产业化、新型键合剂的研制等

近年代表性论文与专利:

1. Jiaxing Hu, Qin Hua-Li, Xu Wengang, Li Junli, Zhang Fanglin, Zheng Hua. TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction [J]. Chem. Commun., 2014, 50(99): 15780-15783.

2. D. Li, Lu B., Huang Z., Xu P., Zheng H., Yin Y., Xu H., Liu X., Chen L., Lou Y., Zhang X., Xiong F. A novel melphalan polymeric prodrug: preparation and property study [J].Carbohydr Polym, 2014, 111:928-935.

3. Chuxiang Sun, Shu Ke, Wang Wei, Ye Zhao, Liu Ting, Gao Yuxiang, Zheng Hua, He Guanghua, Yin Yihua. Encapsulation and controlled release of hydrophilic pesticide in shell cross-linked nanocapsules containing aqueous core [J]. Int. J. Pharm., 2014, 463(1): 108-114.

4. Cheng Gao, Liu Ting, Dang Yinghua, Yu Zhiyan, Wang Wei, Guo Jingjing, Zhang Xueqiong, He Guanghua, Zheng Hua, Yin Yihua, Kong Xiangqi. pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate [J]. Carbohydrate Polymers, 2014, 111: 964-970.

5. Bo Lu, Huang Dan, Zheng Hua, Huang Zhijun, Xu Peihu, Xu Haixing, Yin Yihua, Liu Xia, Li Dan, Zhang Xueqiong. Preparation, characterization, and in vitro efficacy of O-carboxymethyl chitosan conjugate of melphalan [J]. Carbohydr. Polym., 2013, 98(1): 36-42.

6. Yihua Yin, Sha Xu, Dan Chang,HuaZheng, Junli Li, Xiaoping Liu, Peihu Xu, Fuliang Xiong. One-pot synthesis of biopolymeric hollow nanospheres by photocrosslinking.  Chemical Communications, 2010, 46(43): 8222-8224.

7. Xiaoyu Gong, Yihua Yin, Zhijun Huang, Bo Lu, Peihu Xu, Hua Zheng, Fuliang Xiong. Preparation, characterization, and in vitro release study of a glutathione-dependent polymeric prodrug cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan.International Journal of Pharmaceutics2012436: 240-247.

8. Bo Lu, Xu Liu, Zhijun Huang, Haixing Xu, Peihu Xu, Yiting Wang, Hua Zheng, Yihua Yin, Xianzheng Zhang, Renxi Zhuo. Synthesis of diamine maleyl chitosans, and in vitro transfection studies. Carbohydrate Polymers, 2012, 87, 1453-1459.

9. He Guanghua, Wang Zi, Zheng Hua, Yin Yihua, Xiong Xiong. Preparation, characterization and properties of aminoethyl chitin hydrogels. Carbohydrate Polymers, 2012, 90, 1614-1619.

10. Houwei Tu, Yi Qu, Xiaohua Hu, Yihua Yin, Hua Zheng, Peihu Xu, Fuliang Xiong. Study of the sigmoidal swelling kinetics of carboxymethylchitosan-g- poly(acrylic acid) hydrogels intended for colon-specific drug delivery. Carbohydrate Polymers, 2010,82440-445.

11. Yihua Yin, Xianglan Lv, Houwei Tu, Sha Xu, Hua Zheng. Preparation and swelling kinetics of Ph-sensitive photocrosslinked hydrogel based on carboxymethyl chitosan. Journal.of Polymer Research2010, 17: 471-479.

12. Lu B, Wu DQ, Zheng H, Quan CY, Zhang XZ, Zhuo RX. Galactosyl conjugated N-succinyl-chitosan-graft-polyethylenimine for targeting gene transfer. Molecular BioSystems2010, 6, 2529-2538.

13. Hua Zheng, Yan Rao, Yihua Yin, Xiong Xiong, Peihu Xu, Bo Lu. Preparation, characterization, and in vitro drug release behavior of 6-mercaptopurine carboxymethyl chitosan. Carbohydrate Polymers, 2011, 83:1952-1958.

14. Hua Zheng,Xueqiong Zhang, Fuliang Xiong, Zhongjia Zhu, Bo Lu, Yihua Yin, Peihu Xu, Yumin Du. Preparation, characterization, and tissue distribution in mice of lactosaminated carboxymethyl chitosan nanoparticles. Carbohydrate Polymers, 2011, 83:1139-1145.

15. Hua Zheng, Xueqiong Zhang, Yihua Yin, Fuliang Xiong, Xiaoyu Gong, Zhongjia Zhu, Bo Lu, Peihu Xu. In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles. Carbohydrate Polymers, 2011, 84:1048-1053.

16. Ying Yi, Sha Xu, Haikuan Sun, Dan Chang, Yihua Yin, Hua Zheng, Haixing Xu, Yiceng Lou. Gelation of photocrosslinkable carboxymethyl chitosan and its application in controlled release of pesticide. Carbohydrate Polymers,2011,86:1007-1013.

17. Bo Lu, Xu Liu, Zhijun Huang, Haixing Xu, Peihu Xu, Yiting Wang, Hua Zheng, Yihua Yin, Xianzheng Zhang, Penxi Zhuo. Synthesis of diamine maleyl chitasans, and in vitro transfection studies. Carbohydrate Polymers, 2012,87:1453-1459.

18. Dan Chang, Jing Lei, Huiran Cui, Na Lu, Yanjuan Sun, Xiaohua Zhang, Cheng Gao, Hua Zheng, Yihua Yin.Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior.Carbohydrate Polymers, 2012,88:663-669.

19. Ling Kai, Zheng Fei, Li Junli, Tang Rupei, Huang Jin, Xu Yongmei, Zheng Hua, Chen Jinghua. Effects of substitution degree of photoreactive groups on the properties of UV-fabricated chitosan scaffold. Journal of Biomedical Materials Research Part A, 2008, 87(1): 52-61.

20. Xu Yong Mei, Zhan Chang You, Fan Li Hong, Wang Le, Zheng Hua. Preparation of dual crosslinked alginate-chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system. International Journal of Pharmaceutics. 2007, 336 (2): 329-337.

著作

生物质化工与生物质材料,化学工业出版社,20098月,主编。

主要奖励与荣誉

湖北省科技进步一等奖1项、湖北省科技进步二等奖3项、湖北省科技进步三等奖3


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