吕波
性别：男
出生年月：1979年10月
学位：博士
职称与职位：教授
E-Mail：lvb@whut.edu.cn
教育经历
1998.09-2002.06 中国地质大学(武汉)应用化学学士
2003.09-2006.06 武汉大学高分子化学与物理 硕士
2006.09-2009.06 武汉大学生物医用材料教育部重点实验室 博士
研究领域
1．药物新剂型与新技术；
2．生物医用高分子材料；
工作经历
1．2002.09 至2003.04 株洲时代新材料科技股份有限公司
2．2009.06-2011.09 永利集团88304官网 讲师
3. 2011.10-2019.09 永利集团88304官网 副教授
4. 2016.02-2017.02 约翰霍普金斯大学生物医学工程系 访问学者
5. 2019.09- 永利集团88304官网 教授
科研项目
1、自识别自靶向的协同治疗纳米给药系统的构建及应用于白血病治疗研究，2018.01-2021-12，国家自然科学基金委面上项目51773162，主持
2、胞外胞内双重响应的多功能协同增强传递基因载体的构建与评价。国家自然科学基金青年基金21204071，2013.1-2015.12， 主持
3、基于多肽的超支化非病毒基因载体的构建与评价 湖北省自然科学基金 2015.01-2016.12，主持
4、细胞内氧化还原响应模拟病毒基因载体的构建与评价。武汉市晨光计划 201140431092，2011.1-2013.12， 主持5
5、羧甲基壳聚糖肝靶向智能纳米给药系统的构建与评价。中央高校基本科研业务经费专项资金资助2010-IV-009，2010.1-2011.12， 主持
6、基于Catheps in X 响应的抗慢性淋巴白血病主动靶向控释纳米给药系统的构建与评价。国家自然科学基金面上项目51273156，2013.1-2016.12 参与，排名第2。
7、壳聚糖基新型烧伤活性敷料关键技术研发 横向合作 主持
8、水凝胶的抗菌性能检测 横向合作 主持
代表性论文与著作
1. Chen K, Chang C, Liu ZH, Zhou YM, Xu QN, Li CH, Huang ZJ, Xu HX, Xu PH, Lu B*. Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy. Colloids and Surfaces B: Biointerfaces 2020, 194, 111166
2. Chen X, Lu B, Zhou D, Shao M, Xu WL, Zhou YS. Photocrosslinking maleilated hyaluronate/methacrylated poly (vinyl alcohol) nanofibrous mats for hydrogel wound dressings. International Journal of Biological Macromolecules. 2020.155. 903-910
3. Liao JH, Song YJ, Liu C, Li D, Zheng H, Lu B*, Dual-drug delivery based charge-conversional polymeric micelles for enhanced cellular uptake and combination therapy Polymer Chemistry. 2019.10.5879-5893
4. Shao M, Chang C, Liu ZH, Chen K, Zhou YM, Zheng GH, Huang ZJ, Xu HX, Xu PH, Lu B*, Polydopamine coated hollow mesoporous silica nanoparticles as pHsensitive nanocarriers for overcoming multidrug resistance. Colloids and Surfaces B: Biointerfaces 2019, 183, 110427
5. Huang L, Liu J, Gao F, Cheng Q, Zheng H, Xu HX Lu B*, Xu PH, Zhang XZ, Zeng X, A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy. Journal of Materials Chemistry B 2018, 4618-4629.
6. Fu F, Liu X, Lu B*, Qu GY, Zheng H, Huang ZJ, Xu PH, Xu HX, Yin YH, Liu X, Zhang XQ. Synthesis and evaluation of novel chitosan derivatives for gene delivery. Journal of Wuhan University of Technology-Mater.Sci.Ed. 2015, 30(4), 852-858.
7. Tong YX, Liu M, Zhang KC, Cao Y, Dong JJ, Jiang B, Lu B, Zheng H, Zhang HL, Pei RJ. Oligoethylenimine-grafted Chitosan as Enhanced T1 Contrast Agent for in vivo Targeted Tumor Magnetic Resonance Imaging. Journal of Magnetic Resonance Imaging.2015
8. Li D, Lu B*, Huang ZJ, Xu PH, Zheng H, Yin YH, Xu HX, Liu X, Chen LY, Lou YC, Zhang XQ, Xiong FL. A novel melphalan polymeric prodrug: Preparation and property study. Carbohydr. Polym. 2014, 111, 928-935.
9. Li D, Lu B*, Zhang H, Huang ZJ, Xu PH, Zheng H, Yin YH, Xu HX, Liu X, Lou YC, Zhang XQ, Xiong FL. Synthesis and in vitro evaluation of methotrexate conjugated O,N-carboxymethyl chitosan via peptidyl spacers. J. Nanopart Res. 2014, 16: 2609
10. Gong XY, Yin YH, Huang ZJ, Lu B*, Xu PH, Zheng H, Xiong FL, Xu HX, Xiong X, Gu XB. Preparation, characterization and in vitro release study of a glutathione-dependent polymeric prodrug Cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan. Inter. J. Pharm. 2013, 436, 240-247.
11. Lu B, Huang D, Zheng H, Huang ZJ, Xu PH, Xu HX, Yin YH, Liu X, Li D, Zhang XQ. Preparation, characterization, and in vitro efficacy of O-carboxymethyl chitosan conjugate of melphalan. Carbohydr. Polym. 2013, 98, 36-42.
12. Lu B, Liu X, Huang ZJ, Xu HX, Xu PH, Wang YT, Zheng H, Yin YH, Zhang XZ, Zhuo RX.Synthesis of diamine maleyl chitosans, and in vitro transfection studies. Carbohydr. Polym. 2012, 87, 1453-1459.
13. Zheng H, Rao Y, Yin YH, Xiong X, Xu PH, Lu B. Preparation; characterization; and in vitro drug release behavior of 6-mercapto-purine-carboxymethyl chitosan. Carbohydr. Polym. 2011, 83, 1952-1958.
14. Zheng H, Zhang XQ, Xiong FL, Zhu ZJ, Lu B, Yin YH, Xu PH, Du YM. Preparation, characterization, and tissue distribution in mice of lactosaminated carboxymethyl chitosan nanoparticles. Carbohydr. Polym. 2011,83,1139-1145.
15. Zheng H, Zhang XQ, Yin YH, Xiong FL, Gong XY, Zhu ZJ, Lu B, Xu PH. In vitro characterization, and in vivo studies of crosslined lactosaminated carboxymethyl chitosan nanoparticles. Carbohydr. Polym. 2011, 84, 1048-1053.
16. Lu B, Wu DQ, Zheng H, Quan CY, Zhang XZ, Zhuo RX. Galactosyl conjugated N-succinyl-chitosan-graft-polyethylenimine for targeting gene transfer. Molecular biosystems, 2010, 6, 2529-2538.
17. Xu XD, Chen CS, Lu B, Wang ZC, Cheng SX, Jiang XJ, Zhang XZ,* Zhuo RX*. Modular synthesis of thermosensitive P(NIPAAm-co-HEMA)/β-CD based hydrogels via “Click” chemistry. Macromol. Rapid Comm, 2009, 30, 157-164.
18. Wu DQ, Lu B, Chang C, Cheng SX, Zhang XZ,* Zhuo RX*. Galactosylated fluorescent labeled micelles as a liver targeting drug carrier. Biomaterials, 2009, 30, 1363-1371.
19. Lu B, Wang CF, Wu DQ, Li C, Zhang XZ,* Zhuo RX*. Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery. J. Control. Release, 2009, 137, 54-62.
20. Lu B, Sun YX, Li YQ, Zhang XZ,* Zhuo RX*. N-Succinyl-chitosan grafted with low molecular weight polyethylenimine as serum-resistant gene vector. Mol. Biosyst, 2009, 5, 629-637.
21. Lu B, Xu XD, Zhang XZ,* Cheng SX, Zhuo RX*. Low molecular weight polyethylenimine grafted N-maleated chitosan for gene delivery: properties and in vitro transfection Studies. Biomacromolecules, 2008, 9, 2594-2600.
22. Wu DQ, Wang T, Lu B, Xu XD, Cheng SX, Jiang XJ, Zhang XZ,* Zhuo RX*. Fabrication of supramolecular hydrogels for drug delivery and stem cell encapsulation. Langmuir, 2008, 24, 10306-10312.
授权专利
1、 吕波、许然然、付芳、郑化、雷春雨。一种丙酰氧基乙基三甲基氯化铵壳聚糖纤维的制备方法。ZL 2014 1 0663863.7
2、吕波、洪慧、宋豪源、胡英。一种复合海绵及其制备方法。ZL 2016 1 0284376.9