姓名：吴建平
学位：医学博士
职称：教授
Email：biojpwu@whut.edu.cn
教育经历：
1994/09 – 1997/07 武汉同济医科大学，医学，博士
1991/09 – 1994/07 武汉同济医科大学，医学，硕士
1986/09 – 1991/07 武汉同济医科大学，医学，学士
研究经历：
2018.03~至今 永利集团88304官网，永利集团88304官网，教授
2012.03~2018.03 Virginia Tech Carilion School of Medicine, Assistant Professor
2009.10~2012.03 Washington University in St. Louis, Sr. Scientist
2003.07~2009.10 University of Alabama at Birmingham, Research Associate
1999.07~2003.07 Georgia State University, Post-Doc Research Associate
科研概况：
主要从事离子通道、受体及转运蛋白结构与功能的基础研究，在KCNT钾通道、Na+/HCO3-共转运体（NBC）结构功能调控、药物筛选等相关领域进行了系统而深入的研究，取得了若干创新性研究成果。2009建立NBC巨片钳测定方法，在国际上首次观察到PIP2信号途径对NBC活性调控存在不同作用模式（PNAS，2009）。近年来研究兴趣侧重于离子通道、受体在脑血管病、癫痫等重要神经系统疾病的发病机制中作用及临床干预对策研究。
研究领域：
1) 脑血管病：侧重于脑功能保护基础研究及药物研发
2) 中枢神经网络的代谢性调控与癫痫：难治性癫痫发病机制、抗癫痫药物筛选
主要科研项目：
1) “KCNT钾通道功能上调参与脑外伤后癫痫形成发病机制研究”，北京市自然科学基金，主持，2023～2025；
2) “基于多组学大数据的脑血管病新药研发”，中关村医学工程健康产业化基地北京睿思全息科技有限公司，研发主管，2023～2028；
3) “基于NBC活性抑制的新型脑保护剂联合tPA溶栓治疗缺血性卒中应用策略”，绍兴上虞武汉理工高等研究院，主持，2023～2027；
4) “ITPKA/IP4与PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”，国家自然科学基金，主持， 2019～2022；
5) “神经药理基础与创新”，永利集团88304官网，主持， 2018～2023.
专业协会及学术兼职：
1999~至今：Society for Neurosciences(SFN), Member；
2003~至今：American Epilepsy Society(AES), Active Member；
2019~至今：中国卒中学会转化医学分会，委员；
2019~至今：中国医师协会神经修复学专业委员会，委员；
2021~至今：中国抗癫痫学会药物治疗专业委员会，委员；
2022~至今：CNS & Neurological Disorders-Drug Targets，Section Editor; Frontiers in Behavioral Neuroscience, Review Editor
2023~至今：中国工业医学杂志，编委
代表性论文与专利：
For a more complete list of publications, visit the following PubMed site htwww.ncbi.nlm.nih.gov/myncbi/jianping.wu.1/bibliography/public/
1) Jiang PZ, Zahra A, Guo X, Wu J*. Potential role of Sinomenine in cancer management. Pharmacology 2024(in press)
2) Shi X, Liu R, Wang Y, Yu T, Liu C, Zhang K, Zhang C, Hua W, Gua Y, Zhang L, Wu J, Wang Q, Zhu F. Inhibiting acid-sensitive ion channel exerts neuroprotective effects in experimental epilepsy via suppressing ferroptosis. CNS Neurosci Ther 2024(in press)
3) Liu R#, Sun L#, Du L#, Guo X, Jia M, Wang Q, Wu J*. Enhanced KNa1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain Injury.
eLife 2023 Dec 26, 12:RP93304. doi.org/10.7554/eLife.93304.1
4) Jia M#, Guo X#, Liu R, Sun L, Wang Q, Wu J*. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cell Mol Neurobiol. 2023 Dec 17;44(1):5. doi: 10.1007/s10571-023-01435-4.
5) Liu R, Sun L, Shi X, Li C, Guo X, Wang Y, Wang X, Zhang K, Wang Y, Wang Q, Wu J*. Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury. Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1.
6) Guo X, Liu R, Jia M, Wang Q, Wu J*. Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism. Neurochem Res. 2023 Aug;48(8):2320-2334. doi: 10.1007/s11064-023-03923-x.
7) Zahra A, Liu R, Wang J, Wu J*. Identifying the mechanism of action of the Kv7 channel opener, retigabine in the treatment of epilepsy. Neurol Sci. 2023 Jul 13. doi: 10.1007/s10072-023-06955-x.
8) Yan S, Xu C, Yang M, Zhang H, Cheng Y, Xue Z, He Z, Wang T, Bai S, Wang G, Wu J, Tong Z, Cai X. The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress. Neuropharmacology. 2023 May 15; 229:109476. doi: 10.1016/j.neuropharm.2023.109476.
9) Liu R, Sun L, Wang YF, Wang Q, Wu J*. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr; 44(4):1201-1206. doi: 10.1007/s10072-022-06521-x.
10) Zahra A, Liu R, Han W, Meng H, Wan Q, Wang Y, Campbel SL, Wu J*. KCa-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic Indications. Curr Neuropharmacol. 2023;21(7):1504-1518. doi: 10.2174/1570159X21666221208091805.
11) Fan J, Zhao Z, Liu R, Li H, He W, Wu J, Wang Y, Chen W. A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy. Int J Mol Sci 2022, 23, 14505. doi: 10.3390/ijms232314505.
12) Xiong H, Wu J*, Qin HL*. [3+2]Cycloaddition for the assembly of indolizine-based heterocyclic sulfonyl fluorides. Org Chem Front 2022 Nov 22. doi: 10.1039/D2QO01466A
13) Wang J#, Zahra A#, Wang Y, Wu J*. Understanding the physiological role of electroneutral Na+-coupled HCO3− cotransporter and its therapeutic implications. Pharmaceuticals (Basel). 2022,15, 1082. doi.org/10.3390/ph15091082.
14) Zhang Q, Jia M, Zahra A, Wang Y, Wang Q, Campbell SL, Wu J*. Cell death in cerebral ischemia-reperfusion injury. Neurochem Res. 2022 Aug 17. doi: 10.1007/s11064-022-03697-8. Epub ahead of print. PMID: 35976487.
15) Xia H, Zahra A, Jia M, Wang Q, Wang Y, Campbell SL, Wu J*. Na+/H+ exchanger 1, a potential therapeutic drug target for cardiac hypertrophy and heart failure. Pharmaceuticals (Basel). 2022 Jul 15;15(7). doi: 10.3390/ph15070875.
16) Jia M, Zhang Q, Guo X, Liu R, Liu S, Chen N, Wang YF, Wang Q, Wu J*, Campbell SL. Na+/HCO3- Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus. CNS Neurol Disord Drug Targets. 2022 May 17; doi: 10.2174/1871527321666220517121135.
17) Zahra A, Wang Y, Wang Q, Wu J*. Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability. Behav Neurol. 2022; 2022:5893519. doi: 10.1155/2022/5893519.
18) Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J*. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. J Integr Neurosci.2022 Mar 23;21(2):61. doi: 10.31083/j.jin2102061.
19) Sun L, Liu R, Yang H, Yu T, Wu J*, Wang Q*. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats. Neurochem Res. 2022 Feb 1;. doi: 10.1007/s11064-022-03542-y.
20) Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X*, Wu J*. Double-edged Role of KNa Channels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection. Curr Neuropharmacol. 2022;20(5):916-928. doi: 10.2174/1570159X19666211215104829.
21) Du L, Zahra A, Jia M, Wang Q, Wu J*. Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review. Brain Sci. 2021 Sep 26;11(10). doi: 10.3390/brainsci11101276.
22) Sun L, Shan W, Yang H, Liu R, Wu J*, Wang Q*. The Role of Neuroinflammation in Post-traumatic Epilepsy. Front Neurol. 2021;12:646152. doi: 10.3389/fneur.2021.646152.
23) Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B, Qian F, Wu J*. The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases. Life Sci. 2021 Apr 1;270:119153. doi: 10.1016/j.lfs.2021.119153.
24) Martinez-Espinosa PL#, Wu J#, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. elife. 2015 Nov 11;4. doi: 10.7554/eLife.10013.
25) Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107.
26) Wu J, McNicholas CM, Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes. Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14150-5. doi: 10.1073/pnas.0906303106.
27) Wu J, Hablitz JJ. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci. 2005 Jul 6;25(27):6322-8. doi: 10.1523/JNEUROSCI.1405-05.2005.
28) Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F, Jiang C. Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP. J Cell Physiol. 2004 Jan;198(1):73-81. doi: 10.1002/jcp.10388.
29) Wang X, Wu J, Li L, Chen F, Wang R, Jiang C. Hypercapnic acidosis activates KATP channels in vascular smooth muscles. Circ Res. 2003 Jun 13;92(11):1225-32. doi: 10.1161/01.RES.0000075601.95738.6D.
30) Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. J Physiol. 2002 Sep 1;543(Pt 2):495-504. doi: 10.1113/jphysiol.2002.025247.
大会报告
1) 吴建平， KCNT钾通道与脑外伤后癫痫发病机制,中国抗癫痫协会药物治疗专业委员会第三届学术年会（专题报告），广州， 2023.5.20～21。
2) 吴建平，中枢KCNT钾通道功能与外伤后“难治性”癫痫，中国卒中学会第五届学术年会暨天坛国际脑血管病会议（专题报告），北京国家会议中心， 2019.6.28。
3) 吴建平， 基于NBC抑制的神经保护剂研发与临床应用，中国卒中学会“神经修复分会”第二届学术年会（专题报告），重庆国际会议中心， 2021.5.20。
会议墙报、摘要
4) Liu R, Sun L, Wang Q, Wu J. KNa1.1 Channel Aggravates Seizure Susceptibility and Elevates Neuronal Excitability After Traumatic Brain Injury. AES Meeting, 2022, Dec 2, Nashville
5) 郭羲，贾梦，王群，吴建平。NBCs抑制剂S0859对小鼠缺血再灌注损伤后血脑屏障的保护作用。2022.08.22. 中国卒中学会、国家神经系统疾病临床医学研究中心、国家神经系统疾病医疗质量控制中心、全球神经科学与卒中协同会、世界卒中组织（WSO）、 美国心脏协会/美国卒中协会（AHA/ASA）、北京创研医学研究中心。
6) Du L, Zahra A, Wang Q, Wang YF, Wu J. Prenatal Citalopram exposure induced anxiety and depression-like behavior with medial prefrontal cortex dysfunction during adolescence. SFN Meeting, 2021, Chicago
7) Jia M, Chan W, Wang YJ, W Q and Wu J. Inhibition of NBCs activity protects hippocampus CA1 delayed neuronal death induced by transient global cerebral ischemia in gerbils. SFN Meeting, 2019, Chicago
8) Wu J and Friedlander MJ. Regular and irregular (Poisson) conditioning trains induced synaptic plasticity between individual neurons in layer 4 of mouse visual cortex. Abstract for SFN, 2016, San Diego
9) Wu J and Friedlander MJ. Effects of irregular (Poisson) conditioning trains on synaptic plasticity between individual neurons in layer 4 of mouse visual cortex, Abstract for SFN, 2015, Chicago
10) Wu J and Friedlander MJ. Regular and irregular (Poisson) conditioning trains induced synaptic plasticity between individual neurons in layer 4 of mouse visual cortex. Abstract for SFN, 2016, San Diego
11) Wu J and Tyler WJ. Mechanical bioeffects of pulsed ultrasound modulate the activity of TREK-1 potassium channels, Abstract for SFN, 2013, San Diego, CA
12) Wu J, Liu XF, Thornell IM and Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulation of electrogenic Na/bicarbonate cotransporter NBCe1 variants expressed in Xenopus laevis oocytes FASEB J April 22, 2009 23:800.13
13) Wu J, McNicholas-Bevensee CM, Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/bicarbonate cotransporter NBCe1-A. FASEB. J April 18, 2007 21:A1285 (Abstract for EB meeting, 2007, DC)
14) Wu J, Hablitz JJ. Tonic GABAB inhibition regulates neurotransmission in prefrontal cortex. Abstracts for SFN.2005.
15) Wu J, Hablitz JJ. Dopamine-GABAB Interaction in Modulation of EPSCs in Layer I Interneurons. Abstracts for SFN.2004.
16) Wu J, Rojas A, Wang R and Chun Jiang. Gating of the Kir6.2 channel may involve spatial hindrance effct by Phe168 at the intracellular end of the M2 helix bundle-crossing. Abstracts of SFN.2003.
17) Wu J, Piao H, Cui N, Jiang C. Both M1 and M2 domains are required for Gating KATP channel by intracellular ATP. Abstract for Biophysics Meeting 2003, 393-pos
18) Wu J., Xu H., Mao J; C. Jiang. Gating of KATP channel by intercellular proton and ATP. Abstracts of SFN.27: 708.19,2001.
19) Wu J., Xu H. W. Shen; C. Jiang. Colocalization of Kir4.1 and Kir5.1 mRNA in brainstem neurons. Abstracts of SFN. 26: 154.8, 2000.
学术奖励及荣誉：
“National Alliance for Research on Schizophrenia and Depression” Young Investigator Award (NARSD, 2006)